Desarrollo de un modelo basado en la rata alfa-sinucleína para la enfermedad de Parkinson mediante inyección estereotáctica de un vector viral adeno-asociado recombinante

This manuscript describes how viral vector-mediated local gene delivery provides an attractive way to express transgenes in the central nervous system. The protocol outlines all crucial steps to perform a viral vector injection in the substantia nigra of the rat to develop a viral vector-based animal model for Parkinson's disease.